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Scientists from University of Pittsburgh have developed a novel approach to target cancer cells through the insertion of a “suicide gene” (HSV1-tk) into key gene fusion areas of the cancer genome. Targeting gene fusion points remains an elusive goal in cancer therapy. This novel approach can insert HSV1-tk at specific fusion points and could lead to improved survival in cancer patients through initiation of cell death or metastasis inhibition ... University of Pittsburgh researchers have developed a novel light-responsive tau protein (optoTAU) to allow for investigation of tau behavior in cells and to identify molecules that could modify tau aggregation in Alzheimer’s disease and other tauopathies. Dementias, including Alzheimer’s disease (AD ... Researchers from University of Pittsburgh have developed a novel low-cost system, Asclepius, to transform easily available earphones into a stethoscope, allowing clinicians to capture cardiac auscultation remotely. Asclepius makes remote auscultation feasible for the first time, improving the quality of care to patients unable to access in-person clinics ...